IL-17 stimulates granulopoiesis in mice; use of an alternate novel gene therapy-derived method for in vivo evaluation of cytokines

P. Schwarzenberger, V. La Russa, A. Miller, P. Ye, W. Huang, A. Zieske, S. Nelson, G.J. Bagby, D. Stoltz, R.L. Mynatt, M. Spriggs, J.K. Kolls

J Immunol, 1998 Dec 1;161(11):6383-9

 

IL-17 is a novel cytokine secreted principally by CD4+ T cells. It has been shown to support the growth of hemopoietic progenitors in vitro; however, its in vivo effects are presently unknown.